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Neural regulations of the tumor microenvironment.

Anthony C RestainoPaola Drapkin Vermeer
Published in: FASEB bioAdvances (2021)
The identification of nerves in the tumor microenvironment has ushered in a new area of research in cancer biology. Numerous studies demonstrate the presence of various types of peripheral nerves (sympathetic, parasympathetic, sensory) within the tumor microenvironment; moreover, an increased density of nerves in the tumor microenvironment correlates with worse prognosis. In this review, we address the current understanding of nerve-mediated alterations of the tumor microenvironment and how they impact disease through a variety of processes, including direct nerve-cancer cell communication, alteration of the infiltrative immune population, and alteration of stromal components.
Keyphrases
  • papillary thyroid
  • peripheral nerve
  • bone marrow
  • squamous cell
  • blood pressure
  • case control
  • childhood cancer
  • lymph node metastasis