Rhodium(III)-catalyzed regioselective C2-alkenylation of indoles with CF 3 -imidoyl sulfoxonium ylides to give multi-functionalized enamines using a migratable directing group.
Zuguang YangJianhua TangChen LiZhengkai ChenXiao-Feng WuPublished in: Chemical communications (Cambridge, England) (2022)
A rhodium(III)-catalyzed regioselective C2-alkenylation of indoles for the construction of α-CF 3 substituted enamines has been developed, which utilizes CF 3 -imidoyl sulfoxonium ylides (TFISYs) as alkenylating agents for the first time. A wide array of indolyl- and trifluoromethyl-decorated enamine derivatives have been assembled in moderate to good yields.