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Catalytic Domino Three-Component Synthesis of Functionalized Heterocycles from Carbon Dioxide.

Wangyu ShiChang QiaoJordi Benet-BuchholzArjan W Kleij
Published in: ChemSusChem (2023)
A catalytic domino, three-component reaction has been developed for the transformation of carbon dioxide into functionalized six-membered cyclic carbonates. The catalytic process combines an initial carboxylative cyclization of β-epoxy alcohols followed by an oxa-Michael reaction affording an unparalleled scope of heterocyclic structures. The wide range of functional groups, including free-alcohols, empowers the access to a range of products including C 11 -oxo-based bicyclic heterocycles. The versatility of these functionalized carbonates is further complemented by a series of synthetic diversifications. Control experiments are consistent with the first step of this domino process being promoted by a binary Lewis acid/base catalyst, while the second stage only requires catalytic base.
Keyphrases
  • carbon dioxide
  • quantum dots
  • crystal structure
  • molecularly imprinted
  • high resolution
  • escherichia coli
  • ionic liquid
  • acinetobacter baumannii
  • gold nanoparticles
  • pseudomonas aeruginosa
  • electron transfer