Autophagy drives osteogenic differentiation of human gingival mesenchymal stem cells.
Chiara VidoniAlessandra FerraresiEleonora SecomandiLetizia VallinoChiara GardinBarbara ZavanCarmen MortellaroCiro IsidoroPublished in: Cell communication and signaling : CCS (2019)
Autophagy modulation is instrumental for osteoblastic differentiation of HGMSCs. The present findings can be translated into the regenerative cell therapy of maxillary / mandibular bone defects.
Keyphrases
- cell therapy
- mesenchymal stem cells
- cell death
- endoplasmic reticulum stress
- umbilical cord
- stem cells
- endothelial cells
- signaling pathway
- oxidative stress
- cone beam computed tomography
- bone marrow
- bone mineral density
- induced pluripotent stem cells
- vascular smooth muscle cells
- postmenopausal women
- bone regeneration