Metabolic and genetic determinants for progression to severe liver disease in subjects with obesity from the UK Biobank.

Antonio De VincentisFederica TavaglioneRocco SpagnuoloRoberta PujiaDario TuccinardiGianluca MascianàAntonio PicardiRaffaele Antonelli IncalziLuca ValentiStefano Romeo Umberto Vespasiani-Gentilucci

Published in: International journal of obesity (2005) (2021)

Age, WC, type 2 diabetes, and the PNPLA3 variant are the main risk factors for SLD in individuals with obesity. WC is the principal mediator of SLD risk conveyed by increased BMI. BMI category-specific WC-thresholds may refine the SLD risk more accurately than traditional thresholds.

Keyphrases

type diabetes
weight gain
insulin resistance
metabolic syndrome
weight loss
body mass index
high fat diet induced
glycemic control
cardiovascular disease
adipose tissue
skeletal muscle
dna methylation
genome wide
physical activity
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