GWAS of folate metabolism with gene-environment interaction analysis revealed the possible role of lifestyles in the control of blood folate metabolites in Japanese - the J-MICC Study.
Mineko TsukamotoAsahi HishidaTakashi TamuraMako NagayoshiRieko OkadaYoko KuboYasufumi KatoNobuyuki HamajimaYuichiro NishidaChisato ShimanoeRie IbusukiKenichi ShibuyaNaoyuki TakashimaYasuyuki NakamuraMiho KusakabeYohko NakamuraYuriko N KoyanagiIsao OzeTakeshi NishiyamaSadao SuzukiIsao WatanabeDaisuke MatsuiJun OtonariHiroaki IkezakiSakurako Katsuura-KamaoKokichi ArisawaKiyonori KurikiMasahiro NakatochiYukihide MomozawaKenji TakeuchiKenji WakaiKeitaro MatsuoPublished in: Journal of epidemiology (2023)
The present GWAS revealed the folate metabolism-associated genetic loci and gene-environment interactions with drinking and physical activity in Japanese, suggesting the possibility of future personalized CVD prevention.