A reactive oxygen species-responsive covalent organic framework for tumor combination therapy.

Wen-Yan LiJing-Lan KanJing-Jing WanYan-An LiTian SongBo WangQun GuanLe-Le ZhouYu-Bin Dong

Published in: Chemical communications (Cambridge, England) (2023)

Herein, we report the first reactive oxygen species (ROS)-responsive dithioketal-linked covalent organic framework (COF) for synergetic chemotherapy and photodynamic therapy (PDT) of cancer. The singlet oxygen ( 1 O 2 )-responsive COF dissociation and DC_AC50 drug release complement and reinforce each other to allow an efficient combination of PDT and chemotherapy.

Keyphrases

reactive oxygen species
photodynamic therapy
combination therapy
drug release
cancer therapy
drug delivery
fluorescence imaging
locally advanced
water soluble
squamous cell
dendritic cells
squamous cell carcinoma
dna damage
young adults
rectal cancer