Presence of antibody-dependent cellular cytotoxicity (ADCC) against SARS-CoV-2 in COVID-19 plasma.

For Yue TsoSalum J LidengeLisa K PoppePhoebe B PeñaSara R PrivattSydney J BennettJohn R NgowiJulius MwaiselageMichael BelshanJacob A SiedlikMorgan A RaineJuan B OchoaJulia Garcia-DiazBobby NossamanLyndsey BucknerW Mark RobertsMatthew J DeanAugusto C OchoaJohn T WestCharles Wood

Published in: PloS one (2021)

Both neutralizing and non-neutralizing COVID-19 plasmas can mediate ADCC. Our findings argue that evaluation of potential vaccines against SARS-CoV-2 should include investigation of the magnitude and durability of ADCC, in addition to nAb.

Keyphrases

sars cov
respiratory syndrome coronavirus
dengue virus
coronavirus disease
tyrosine kinase
epidermal growth factor receptor