Evaluating Polygenic Risk Scores for Breast Cancer in Women of African Ancestry.
Zhaohui DuGuimin GaoBabatunde AdedokunThomas U AhearnKathryn L LunettaGary ZirpoliMelissa A TroesterEdward A Ruiz-NarváezStephen A HaddadParichoy PalChoudhuryJonine D FigueroaEsther M JohnLeslie BernsteinWei ZhengJennifer J HuRegina G ZieglerSarah J NyanteElisa V BanderaSue Ann InglesNicholas MancusoMichael F PressSandra L DemingJorge L Rodriguez-GilSong YaoTemidayo O OgundiranOladosu OjengbeManjeet K BollaJoe G DennisAlison M DunningDouglas F EastonKyriaki MichailidouPaul D P PharoahDale R SandlerJack A TaylorQin WangClarice R WeinbergCari M KitaharaWilliam BlotKatherine L NathansonAnselm HennisBarbara NemesureStefan AmbsLara E Sucheston-CampbellJeannette T BensenStephen J ChanockAndrew F OlshanChristine B AmbrosoneOlufunmilayo I OlopadeJoel YarneyBaffour AwuahBeatrice Wiafe-AddaiDavid V Continull nullJulie R PalmerMontserrat Garcia-ClosasDezheng HuoChristopher A HaimanPublished in: Journal of the National Cancer Institute (2022)
The PRSs stratify BC risk in women of African ancestry, with attenuated performance compared with that reported in European, Asian, and Latina populations. Future work is needed to improve BC risk stratification for women of African ancestry.