The Role of Uric Acid in the Acute Myocardial Infarction: A Narrative Review.
Atalay DemirayBaris AfsarAdrian CovicMasanari KuwabaraCharles Joseph FerroMiguel A LanaspaRichard J JohnsonMehmet KanbayPublished in: Angiology (2021)
Increased serum uric acid (SUA) levels have been associated with various pathologic processes such as increased oxidative stress, inflammation, and endothelial dysfunction. Thus, it is not surprising that increased SUA is associated with various adverse outcomes including cardiovascular (CV) diseases. Recent epidemiological evidence suggests that increased SUA may be related to acute myocardial infarction (AMI). Accumulating data also showed that elevated UA has pathophysiological role in the development of AMI. However, there are also studies showing that SUA is not related to the risk of AMI. In this narrative review, we summarized the recent literature data regarding SUA and AMI after providing some background information for the association between UA and coronary artery disease. Future studies will show whether decreasing SUA levels is beneficial for outcomes related to AMI and the optimum SUA levels for best outcomes in CV diseases.
Keyphrases
- acute myocardial infarction
- uric acid
- percutaneous coronary intervention
- oxidative stress
- coronary artery disease
- metabolic syndrome
- left ventricular
- electronic health record
- acute coronary syndrome
- coronary artery bypass grafting
- systematic review
- big data
- neoadjuvant chemotherapy
- dna damage
- heart failure
- healthcare
- squamous cell carcinoma
- adipose tissue
- current status
- type diabetes
- health information
- data analysis
- cardiovascular disease
- atrial fibrillation
- skeletal muscle
- glycemic control
- insulin resistance
- ejection fraction
- aortic valve
- weight loss