Influence of the treatment with the antineoplastic agents 5-fluorouracil and cisplatin on the severity of experimental periodontitis in rats.

Vivian Cristina Noronha Novaes Edilson ErvolinoGiovani Lopes FernandesClara Possarle CunhaLeticia Helena Theodoro Valdir Gouveia Garcia Juliano Milanezi de Almeida

Published in: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2021)

Chemotherapy with antineoplastic agents 5-FU and CIS increased the intensity and duration of the inflammation and compromised tissue repair by reduction in cellular and vascular turnover. The more severe periodontal breakdown was caused by 5-FU.

Keyphrases

oxidative stress
high intensity
bone mineral density
early onset
locally advanced
combination therapy
squamous cell carcinoma
drug induced