Whole-genome DNA hyper-methylation in iPSC-derived dopaminergic neurons from Parkinson's disease patients.
Rubén Fernández-SantiagoAngelika MerkelGiancarlo CastellanoSimon HeathÁngel RayaEduard TolosaMaría-José MartíAntonella ConsiglioMario EzquerraPublished in: Clinical epigenetics (2019)
This study implements previous epigenetic knowledge in PD at a whole genome level providing the first comprehensive and unbiased CpG DNA methylation data using iPSC-derived DAn from PD patients. Our results indicate that DAn from monogenic or sporadic PD exhibit global DNA hyper-methylation changes. Findings from this exploratory study are to be validated in further studies analyzing other PD cell models and patient tissues.
Keyphrases
- dna methylation
- end stage renal disease
- ejection fraction
- gene expression
- newly diagnosed
- genome wide
- chronic kidney disease
- healthcare
- prognostic factors
- spinal cord
- spinal cord injury
- cell free
- electronic health record
- circulating tumor
- case report
- single cell
- deep learning
- big data
- amyotrophic lateral sclerosis
- data analysis
- patient reported
- nucleic acid
- circulating tumor cells