DDX58 Is Associated With Susceptibility to Severe Influenza Virus Infection in Children and Adolescents.

Sanghun LeeYu ZhangMargaret NewhamsTanya NovakPaul G ThomasPeter M MouraniMark W HallLaura L LoftisNatalie Z CvijanovichKeiko M TarquinioAdam J SchwarzScott L WeissNeal J ThomasBarry MarkovitzMelissa L CullimoreRonald C SandersMatt S ZinterJanice E SullivanNatasha B HalasaMelania M BembeaJohn S GiulianoKatri V TyppoRyan A NofzigerSteven L SheinMichele KongBria M CoatesScott T WeissChristoph LangeHelen C SuAdrienne G Randolphnull null

Published in: The Journal of infectious diseases (2022)

We provide evidence associating common gene variants in DDX58 with susceptibility to severe influenza infection in children. RIG-I may be essential for preventing life-threatening influenza-associated disease.

Keyphrases

copy number
early onset
young adults
drug induced
gene expression