Chronic antipsychotic treatment targets GIRK current suppression, loss of long-term synaptic depression and behavioural sensitization in a mouse model of amphetamine psychosis.
Dominik GroosFang ZhengManfred RauhBenedikt QuingerJohannes KornhuberChristian P MüllerChristian AlzheimerPublished in: Journal of psychopharmacology (Oxford, England) (2018)
Our data provide evidence for aberrant neuronal function and plasticity in the mesolimbic dopamine system during an induced psychotic state and identify these alterations as targets of chronic APD treatment.