Secretoglobin superfamily protein SCGB3A2 deficiency potentiates ovalbumin-induced allergic pulmonary inflammation.
Taketomo KidoMitsuhiro YonedaYan CaiTsutomu MatsubaraJerrold M WardShioko KimuraPublished in: Mediators of inflammation (2014)
Secretoglobin (SCGB) 3A2, a cytokine-like secretory protein of small molecular weight, which may play a role in lung inflammation, is predominantly expressed in airway epithelial cells. In order to understand the physiological role of SCGB3A2, Scgb3a2(-/-) mice were generated and characterized. Scgb3a2(-/-) mice did not exhibit any overt phenotypes. In ovalbumin- (OVA-) induced airway allergy inflammation model, Scgb3a2(-/-) mice in mixed background showed a decreased OVA-induced airway inflammation, while six times C57BL/6NCr backcrossed congenic Scgb3a2(-/-) mice showed a slight exacerbation of OVA-induced airway inflammation as compared to wild-type littermates. These results indicate that the loss of SCGB3A2 function was influenced by a modifier gene(s) in mixed genetic background and suggest that SCGB3A2 has anti-inflammatory property. The results further suggest the possible use of recombinant human SCGB3A2 as an anti-inflammatory agent.
Keyphrases
- wild type
- high glucose
- diabetic rats
- oxidative stress
- anti inflammatory
- drug induced
- chronic obstructive pulmonary disease
- type diabetes
- pulmonary hypertension
- intensive care unit
- gene expression
- dna methylation
- metabolic syndrome
- small molecule
- transcription factor
- insulin resistance
- protein protein
- mechanical ventilation