Prognostic Value of Stromal Tumor-Infiltrating Lymphocytes in Young, Node-Negative, Triple-Negative Breast Cancer Patients Who Did Not Receive (neo)Adjuvant Systemic Therapy.
Vincent M T de JongYuwei WangNatalie D Ter HoeveMark OpdamNikolas StathonikosKatarzyna JóźwiakMichael HauptmannSten CornelissenWillem VreulsEfraim H RosenbergEsther A KoopZsuzsanna VargaCarolien H M van DeurzenAntien L MooyaartAlicia Córdoba IturriagagoitiaEmma J GroenJoost BartStefan M WillemsVasiliki ZolotaJelle WesselingAnna SapinoEwa ChmielikAleš RyškaAnnegien BroeksAdri C VoogdSherene LoiStefan MichielsGabe S SonkeElsken van der WallSabine SieslingPaul J van DiestMarjanka K SchmidtMarleen KokGwen M H E DackusRoberto SalgadoSabine C LinnPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2022)
Chemotherapy-naïve, young patients with N0 TNBC with high sTILs (≥ 75%) have an excellent long-term prognosis. Therefore, sTILs should be considered for prospective clinical trials investigating (neo)adjuvant chemotherapy de-escalation strategies.