A potential future Fontan modification: preliminary in vitro data of a pressure-generating tube from engineered heart tissue.
Maria KöhneCharlotta Sophie BehrensTim StüdemannConstantin von BibraEva QuerdelAya ShibamiyaBirgit GeertzJakob OlfeIda HünersStefan JockenhövelMichael HüblerThomas EschenhagenJörg Siegmar SachwehFlorian WeinbergerDaniel BiermannPublished in: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2022)
A simple tube-shaped contractile EHT was generated from human-induced pluripotent stem cells and developed a synchronous beating pattern. Further steps need to focus on optimizing support materials, flow rates and geometry to obtain a construct that creates sufficient pressures to support a directed and pulsatile blood flow.