Targeted Resequencing of the Coding Sequence of 38 Genes Near Breast Cancer GWAS Loci in a Large Case-Control Study.

Brennan Decker Jamie AllenCraig LuccariniKaren A PooleyMitul ShahManjeet K BollaQin WangShahana AhmedCaroline BaynesDon M ConroyJudith BrownRobert N LubenElaine A OstranderPaul D P PharoahAlison M DunningDouglas F Easton

Published in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2019)

We tested the hypothesis that rare variants in 38 genes near breast cancer GWAS loci may mediate risk. These variants do not appear to play a major role in breast cancer heritability.

Keyphrases

genome wide
copy number
genome wide association study
dna methylation
bioinformatics analysis
genome wide identification
gene expression
transcription factor