Central and peripheral modulation of gastrointestinal transit in mice by DN-9, a multifunctional opioid/NPFF receptor agonist.

Biao XuYuanyuan GuoMengna ZhangRun ZhangDan ChenQinqin ZhangJian XiaoKangtai XuNing LiYu QiuHanwen ZhuJiandong NiuXiaoyu ZhangQuan Fang

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2020)

Intracerebroventricular and intraperitoneal administrations of DN-9 inhibit GI transit via opioid receptors in mice by central and peripheral mechanisms, respectively. In addition, the NPFF agonism of DN-9 possesses antiopioid effects on GI transit, which might explain the reduced constipation at the antinociceptive doses.

Keyphrases

chronic pain
pain management
high fat diet induced
drug delivery
chemotherapy induced
cancer therapy
type diabetes
skeletal muscle
metal organic framework