Genome-Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 Participants.
William J YoungPeter J van der MostTraci M BartzMaxime M BosGinevra BiinoThuyVy DuongLuisa FocoJesus T LomincharMartina Müller-NurasyidGiuseppe Giovanni NardoneAlessandro PecoriJulia RamirezLinda RepettoKatharina SchrammXia ShenStefan van DuijvenbodenDiana van HeemstStefan WeissJie YaoJan-Walter BenjaminsAlvaro AlonsoBeatrice SpedicatiMary L BiggsJennifer A BrodyMarcus DörrChristian FuchsbergerMartin GögeleXiuqing GuoMohammad Arfan IkramJohan Wouter JukemaStefan KääbJørgen Kim Kantersnull nullHenry J LinAllan LinnebergMatthias NauckIlja Maria NolteGiulia PianigianiAurora SantinElsayed Z SolimanPaola TesolinSimona VaccargiuMelanie WaldenbergerPim van der HarstNiek VerweijDan E ArkingMaria Pina ConcasAlessandro De GrandiGiorgia GirottoNiels GrarupMaryam KavousiDennis O Mook-KanamoriPau NavarroMichele OriniSandosh PadmanabhanCristian PattaroAnnette PetersMario PirastuPeter Paul PramstallerSusan R HeckbertMoritz F SinnerHarold SniederUwe VölkerJames F WilsonW James GaudermanPier D LambiaseNona SotoodehniaAndrew TinkerHelen R WarrenRaymond NoordamPatricia B MunroePublished in: Journal of the American Heart Association (2024)
We have found limited support for an interaction effect of serum calcium on QT and JT variant associations despite sample sizes with suitable power to detect relevant effects. Therefore, such effects are unlikely to explain a meaningful proportion of the heritability of QT and JT, and factors including rare variation and other environmental interactions need to be considered.