Spexin Diminishes Atrial Fibrillation Vulnerability by Acting on Galanin Receptor 2.
Desheng LiYang LiuChangzhu LiZhiwen ZhouKangyi GaoHairong BaJiming YangGenlong XueDechun YinXinbo ZhaoKewei ShenLingmin ZhangJialiang LiChenhong LiJiahui SongLexin ZhaoYao PeiLina XuanYang ZhangYanjie LuZhi-Ren ZhangBaofeng YangYue LiZhen-Wei PanPublished in: Circulation (2024)
Spexin reduces atrial fibrillation susceptibility by inhibiting CREB phosphorylation and thus downregulating KCNJ2 and SLN transcription by GALR2 receptor. The spexin/GALR2/CREB signaling pathway represents a novel therapeutic avenue in the development of agents against atrial fibrillation.
Keyphrases
- atrial fibrillation
- signaling pathway
- catheter ablation
- oral anticoagulants
- left atrial
- left atrial appendage
- direct oral anticoagulants
- heart failure
- percutaneous coronary intervention
- climate change
- transcription factor
- epithelial mesenchymal transition
- pi k akt
- venous thromboembolism
- early stage
- oxidative stress
- protein kinase