Morphofunctional analysis of fibroblast-like synoviocytes in human rheumatoid arthritis and mouse collagen-induced arthritis.

Camilla Ribeiro Lima MachadoFelipe Ferraz DiasGustavo Gomes ResendePatrícia Gnieslaw de OliveiraRicardo Machado XavierMarcus Vinicius Melo de AndradeAdriana Maria Kakehasi

Published in: Advances in rheumatology (London, England) (2023)

This study provides a comprehensive understanding of the biology of RA-FLS and CIA-FLS. The differences and similarities in ultrastructural morphology and important inflammatory cytokines shown, contribute to future in vitro studies using RA-FLS and CIA-FLS, in addition, they indicate that the adoption of CIA-FLS for studies should take careful and be well designed, since they do not completely resemble human diseases.

Keyphrases

rheumatoid arthritis
endothelial cells
disease activity
high glucose
induced pluripotent stem cells
ankylosing spondylitis
interstitial lung disease
case control
oxidative stress
current status
wound healing
electronic health record