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Morphofunctional analysis of fibroblast-like synoviocytes in human rheumatoid arthritis and mouse collagen-induced arthritis.

Camilla Ribeiro Lima MachadoFelipe Ferraz DiasGustavo Gomes ResendePatrícia Gnieslaw de OliveiraRicardo Machado XavierMarcus Vinicius Melo de AndradeAdriana Maria Kakehasi
Published in: Advances in rheumatology (London, England) (2023)
This study provides a comprehensive understanding of the biology of RA-FLS and CIA-FLS. The differences and similarities in ultrastructural morphology and important inflammatory cytokines shown, contribute to future in vitro studies using RA-FLS and CIA-FLS, in addition, they indicate that the adoption of CIA-FLS for studies should take careful and be well designed, since they do not completely resemble human diseases.
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