Antidepressant use and orthostatic hypotension in older adults living with mild-to-moderate Alzheimer disease.

Adam H DyerClaire MurphyRobert BriggsBrian LawlorSean P Kennellynull null

Published in: International journal of geriatric psychiatry (2020)

In older adults with AD, antidepressants were associated with a significantly greater SBP/DBP drop at 5 minutes. SSRI use in particular may be a risk factor for OH. This emphasises the need to screen older antidepressant users, and particularly those with AD, for ongoing orthostatic symptoms in order to reduce the risk of falls in this vulnerable cohort.

Keyphrases

major depressive disorder
physical activity
community dwelling
bipolar disorder
high throughput
mild cognitive impairment
middle aged
sleep quality