NET-borne elastase prevents inflammatory relapse in intercritical gout.

Lei LiuLizhen ShanHan WangChristine SchauerJanina SchoenLingjiang ZhuCi LuZitao WangYu XueHuaxiang WuHerrmann Martin

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2022)

ULT causes shrinkage of the tophi reflected by an increase of the level of serum cell-free DNA. In the resolution phase of murine tophi, the NET-associated neutrophil elastase degrades proinflammatory cytokines and, thus, ameliorates inflammation.

Keyphrases

oxidative stress
mouse model
uric acid
single molecule