Serotonergic neurotransmission in limbic regions may reflect therapeutic response of depressive patients: A PET study with 11C-WAY-100635 and 18F-MPPF.

Soichiro KitamuraYasuyuki KimuraKeisuke TakahataSho MoriguchiManabu KubotaHitoshi ShimadaHironobu EndoYuhei TakadoKazunori KawamuraMing-Rong ZhangTetsuya SuharaMakoto Higuchi

Published in: The international journal of neuropsychopharmacology (2023)

These results suggest a diversity of antidepressant-induced extracellular 5-HT elevations in the limbic system among depressive patients, which is associated with the individual variability of clinical symptoms following the treatment.

Keyphrases

end stage renal disease
chronic kidney disease
newly diagnosed
prognostic factors
bipolar disorder
major depressive disorder
oxidative stress
pet imaging
combination therapy
patient reported