Survivability of Titanium Implant Materials: In Vitro Simulated Inflammatory and Infectious Environment.
Kai Yuan ChengPuranjay GuptaHemalatha KanniyappanHamza ZahurullahYani SunMostafa AlhamadMathew Thoppil MathewPublished in: Annals of biomedical engineering (2023)
Titanium-based implants utilized in total joint arthroplasties could restore primary musculoskeletal function to patients suffering from osteoarthritis and other conditions. Implants are susceptible to failure stemming from aseptic loosening and infection at the joint site, eventually requiring revision surgery. We hypothesized that there might be a feedback loop by which metal degradation particles and ions released from the implant decrease cell viability and increase immune response, thereby creating biochemical conditions that increase the corrosion rate and release more metal ions. This study focused on the synergistic process through cell viability assays and electrochemical tests. From the results, inflammatory conditions from ion release resulting in cell death would further increase the corrosion rate at the metal implant site. The synergistic interaction in the implant surroundings in which infectious conditions produce Ti ions that contribute to more infection, creating a potential cycle of accelerating corrosion.
Keyphrases
- soft tissue
- cell death
- immune response
- end stage renal disease
- chronic kidney disease
- ejection fraction
- oxidative stress
- minimally invasive
- newly diagnosed
- total knee arthroplasty
- rheumatoid arthritis
- prognostic factors
- transcription factor
- aqueous solution
- cell proliferation
- ionic liquid
- high resolution
- toll like receptor
- acute coronary syndrome
- total hip arthroplasty
- molecularly imprinted
- cell cycle arrest