High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing γδ T cells.
Satoshi NakamizoTetsuya HondaAkimasa AdachiTakahiro NagatakeJun KunisawaAkihiko KitohAtsushi OtsukaTeruki DainichiTakashi NomuraFlorent GinhouxKoichi IkutaGyohei EgawaKenji KabashimaPublished in: Scientific reports (2017)
Psoriasis is a common, chronic inflammatory skin disease characterized by epidermal hyperplasia via the IL-23/IL-17 axis. Various studies have indicated the association between obesity and psoriasis, however, the underlying mechanisms remains unclarified. To this end, we focused on high-fat diet (HFD) in this study, because HFD is suggested as a contributor to obesity, and HFD-fed mice exhibit exacerbated psoriatic dermatitis. Using murine imiquimod (IMQ)-induced psoriasis and HFD-induced obesity models, we have revealed a novel mechanism of HFD-induced exacerbation of psoriatic dermatitis. HFD-fed mice exhibited aggravated psoriatic dermatitis, which was accompanied with increased accumulation of IL-17A-producing Vγ4+ γδ T cells in the skin. HFD also induced the increase of Vγ4+ γδ T cells in other organs such as skin draining lymph nodes, which preceded the increase of them in the skin. In addition, HFD-fed mice displayed increased expression of several γδ T cell-recruiting chemokines in the skin. On the other hand, ob/ob mice, another model of murine obesity on normal diet, did not exhibit aggravated psoriatic dermatitis nor accumulation of γδ T cells in the dermis. These results indicate that HFD is a key element in exacerbation of IMQ-induced psoriatic dermatitis, and further raise the possibility of HFD as a factor that links obesity and psoriasis.
Keyphrases
- high fat diet
- insulin resistance
- high fat diet induced
- adipose tissue
- metabolic syndrome
- rheumatoid arthritis
- high glucose
- type diabetes
- skeletal muscle
- weight loss
- atopic dermatitis
- diabetic rats
- disease activity
- ankylosing spondylitis
- lymph node
- drug induced
- wound healing
- chronic obstructive pulmonary disease
- soft tissue
- weight gain
- oxidative stress
- physical activity
- body mass index
- long non coding rna
- wild type
- respiratory failure
- neoadjuvant chemotherapy
- extracorporeal membrane oxygenation
- hidradenitis suppurativa