DNA crosslinking and recombination-activating genes 1/2 (RAG1/2) are required for oncogenic splicing in acute lymphoblastic leukemia.
Hao ZhangNuo ChengZhihui LiLing BaiChengli FangYuwen LiWeina ZhangXue DongMinghao JiangYang LiangSujiang ZhangJianqing MiJiang ZhuYu ZhangSai-Juan ChenYajie ZhaoXiang-Qin WengWeiguo HuZhu ChenJinyan HuangGuoyu MengPublished in: Cancer communications (London, England) (2021)
All these results suggest that DUX4/IGH-driven DNA crosslinking is required for RAG1/2 recruitment onto the double tandem DRE-DRE sites, catalyzing V(D)J-like recombination and oncogenic splicing in acute lymphoblastic leukemia.
Keyphrases
- acute lymphoblastic leukemia
- circulating tumor
- cell free
- dna repair
- allogeneic hematopoietic stem cell transplantation
- dna damage
- single molecule
- transcription factor
- signaling pathway
- genome wide
- circulating tumor cells
- dna methylation
- gene expression
- oxidative stress
- acute myeloid leukemia
- bioinformatics analysis