A review of the toxicity of ingredients in e-cigarettes, including those ingredients having the FDA's "Generally Recognized as Safe (GRAS)" regulatory status for use in food.
Nada O F KassemRobert M StronginAndrea M StroupMarielle C BrinkmanAhmad El HellaniHanno C ErythropelArash EtemadiVernat ExilMaciej Lukasz GoniewiczNoura O KassemTheodore P KlupinskiSandy LilesThivanka MuthumalageAlexandra NoëlDavid H PeytonQixin WangIrfan RahmanLuis G ValerioPublished in: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco (2024)
The rise in prevalence of e-cigarette use and emerging evidence of adverse effects, particularly on lung health, warrant assessing all aspects of e-cigarette toxicity. One development is manufacturers' stated or implied claims of the safety of using e-cigarette products containing ingredients determined to be "Generally Recognized As Safe" (GRAS) for use in food. Such claims, typically placed on e-cigarette product labels and used in marketing, are unfounded, as pointed out by the United States Food and Drug Administration (FDA)1 and the Flavor and Extract Manufacturers Association (FEMA)2. Assessment of inhalation health risks of all ingredients used in e-liquids, including those claimed to be GRAS, is warranted.