Pannexin-1 Deficiency Decreases Epileptic Activity in Mice.

Mark S AquilinoPaige A Whyte-Fagundes Mark K LukewichLiang ZhangBerj L BardakjianGeorg R ZoidlPeter L Carlen

Published in: International journal of molecular sciences (2020)

These results suggest that Panx1 plays a pivotal role in maintaining neuronal hyperexcitability in epilepsy models and that genetic or pharmacological targeting of Panx1 has anti-convulsant effects.

Keyphrases

high fat diet induced
genome wide
cancer therapy
cerebral ischemia
replacement therapy
skeletal muscle
drug delivery
insulin resistance
blood brain barrier