Toward precision prescribing for methadone: Determinants of methadone deposition.

Andrew H TalalYuxin DingCharles S VenutoLindsay M ChakanAnthony McLeodArpan DhariaGene D MorseLawrence S BrownMarianthi MarkatouEvan D Kharasch

Published in: PloS one (2020)

Genetic analysis, especially in minority populations, is essential to delivering individualized treatments. Although the principal methadone metabolizing enzyme remains controversial, our results suggest that sex, CYP2B6 genotype, and BMI should be incorporated into multivariate models to create methadone dosing algorithms. Methadone dosing algorithms should facilitate medication delivery, improve patient satisfaction, and diminish overdose potential.

Keyphrases

patient satisfaction
machine learning
deep learning
primary care
healthcare
body mass index
emergency department
risk assessment
weight gain
data analysis