Hypoglycaemia in type 2 diabetes exacerbates amyloid-related proteins associated with dementia.
Abu Saleh Md MoinAhmed Al-QaissiThozhukat SathyapalanStephen L AtkinAlexandra E ButlerPublished in: Diabetes, obesity & metabolism (2020)
The AD-associated protein pattern found in T2D, with basal elevated APP and reduced SNCA, was exaggerated by hypoglycaemia with increased APP and decreased SNCA. Additional AD-associated protein levels that changed in response to hypoglycaemia, particularly in T2D, included amyloid P-component, microtubule-associated protein tau, apolipoproteins A1 and E3, pappalysin and noggin. These results are in accordance with the reported detrimental effects of hypoglycaemia.