Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration.

Nicolai FranzmeierM Suárez-CalvetLukas FrontzkowskiAnnah MooreTimothy J HohmanEstrella Morenas-RodriguezBrigitte NuscherLeslie ShawJohn Q TrojanowskiMartin DichgansGernot KleinbergerChristian HaassMichael Ewersnull null

Published in: Molecular neurodegeneration (2020)

Our results suggest that a higher CSF sTREM2 levels are associated with attenuated ApoE4-related risk for future cognitive decline and AD-typical neurodegeneration. These findings provide further evidence that TREM2 may be protective against the development of AD.

Keyphrases

cognitive decline
mild cognitive impairment
type diabetes
metabolic syndrome
skeletal muscle
drug induced
high fat diet