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EBV-positive high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements: a multi-institutional study.

Hui LiuZijun Y Xu-MonetteGuilin TangWei WangYoung KimJi YuanYu LiWeina ChenYanping LiGeorge Y FedoriwFeng ZhuXiaosheng FangCatherine LuedkeL Jeffrey MedeirosKen H YoungShimin Hu
Published in: Histopathology (2021)
EBV infection in DHL/THL is rare (~1.5%). Cases of EBV+ DHL/THL are largely similar to their EBV-negative counterparts clinicopathologically. Our findings expand the spectrum of EBV+ B-cell lymphomas currently recognized in the WHO classification and suggest differences between EBV+ MYC/BCL2 and MYC/BCL6 DHL that may have therapeutic implications.
Keyphrases
  • epstein barr virus
  • diffuse large b cell lymphoma
  • high grade
  • transcription factor
  • machine learning
  • deep learning
  • low grade