EBV-positive high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements: a multi-institutional study.

Hui LiuZijun Y Xu-MonetteGuilin TangWei WangYoung KimJi YuanYu LiWeina ChenYanping LiGeorge Y FedoriwFeng ZhuXiaosheng FangCatherine LuedkeL Jeffrey MedeirosKen H YoungShimin Hu

Published in: Histopathology (2021)

EBV infection in DHL/THL is rare (~1.5%). Cases of EBV+ DHL/THL are largely similar to their EBV-negative counterparts clinicopathologically. Our findings expand the spectrum of EBV+ B-cell lymphomas currently recognized in the WHO classification and suggest differences between EBV+ MYC/BCL2 and MYC/BCL6 DHL that may have therapeutic implications.

Keyphrases

epstein barr virus
diffuse large b cell lymphoma
high grade
transcription factor
machine learning
deep learning
low grade