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METTL1 mediated tRNA m 7 G modification promotes leukaemogenesis of AML via tRNA regulated translational control.
Pan Zhao
Lin Xia
Dan Chen
Wei Xu
Huanping Guo
Yinying Xu
Bingbing Yan
Xiao Wu
Yuxia Li
Yunfang Zhang
Xi Zhang
Published in:
Experimental hematology & oncology (2024)
Taken together, our study demonstrates the important role of METTL1/WDR4 in AML leukaemogenesis, which provides a promising target candidate for AML therapy.
Keyphrases
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acute myeloid leukemia
allogeneic hematopoietic stem cell transplantation
transcription factor
acute lymphoblastic leukemia
mesenchymal stem cells
smoking cessation