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Daptomycin Plasma and CSF Levels in Patients with Healthcare-Associated Meningitis.

Simone PivaAntonello Di PaoloLaura GaleottiFrancesco CeccheriniFrancesco CordoniLiana SignoriniTommaso TogniAmedeo De NicolòFrank A RasuloNazzareno FagoniN LatronicoAntonio D'Avolio
Published in: Neurocritical care (2020)
Our POP/PK model was able to describe the pharmacokinetics of daptomycin in both plasma and CSF, showing that daptomycin (up to 7 days at 10 mg/kg) has minimal penetration into central nervous system. Furthermore, the observed variability of AUC, tmax and predicted concentration in CSF was lower than what previously reported in the literature. Based on the present findings, it is unlikely that daptomycin could reach CSF concentrations high enough to have clinical efficacy; this should be tested in future studies.
Keyphrases
  • methicillin resistant staphylococcus aureus
  • cerebrospinal fluid
  • healthcare
  • systematic review
  • staphylococcus aureus
  • social media