Early systemic insults following traumatic brain injury: association with biomarker profiles, therapy for intracranial hypertension, and neurological outcomes-an analysis of CENTER-TBI data.
Chiara RobbaFrancesca GrazianoEdoardo PicettiCecilia ÅkerlundAlberto AddisGiuseppe PastoreMattia SiveroPaola ReboraStefania GalimbertiNino StocchettiAndrew MaasDavid K MenonGuiseppe Citerionull nullPublished in: Intensive care medicine (2024)
Though less frequent than previously described, SIs in TBI patients are associated with higher release of neuronal than glial injury biomarkers and with increased requirements for ICU therapies aimed at reducing intracranial hypertension. Hypotension or combined SIs are significantly associated with adverse 6-month outcomes. Current criteria for hypotension may lead to higher biomarker levels and more negative outcomes than those for hypoxemia suggesting a need to revisit pressure targets in the prehospital settings.
Keyphrases
- traumatic brain injury
- blood pressure
- end stage renal disease
- ejection fraction
- intensive care unit
- severe traumatic brain injury
- newly diagnosed
- cardiac arrest
- type diabetes
- peritoneal dialysis
- emergency department
- optical coherence tomography
- optic nerve
- electronic health record
- neuropathic pain
- mechanical ventilation
- deep learning
- cerebral ischemia
- brain injury
- blood brain barrier