Empirical carbapenems or piperacillin/tazobactam for infections in intensive care: An international retrospective cohort study.

Nick Meier Marie Warrer Munch Anders GranholmAnders PernerFrederik Boetius HertzBalasubramanian VenkateshNaomi E HammondQiang LiLiesbet De BusJan De WaeleEvaldas KauzonasFredrik SjövallMorten Hylander MøllerMarie Helleberg

Published in: Acta anaesthesiologica Scandinavica (2024)

In this post hoc analysis of ICU patients with infections, we found widespread initial use of carbapenems and piperacillin/tazobactam in international ICUs, with the latter being more frequently used. Randomized clinical trials are needed to assess if the observed variations in outcomes may be drug-related effects or due to confounders.

Keyphrases

gram negative
intensive care unit
mechanical ventilation
emergency department
type diabetes
multidrug resistant
adipose tissue
acute respiratory distress syndrome
weight loss
electronic health record