Prognostic role of tumour-associated macrophages and regulatory T cells in EBV-positive and EBV-negative nasopharyngeal carcinoma.
Marc Lucas OoftJolique A van IpenburgMaxime E SandersMariette KranendonkIngrid HoflandRemco de BreeSenada KoljenovićStefan M WillemsPublished in: Journal of clinical pathology (2017)
FOXP3, a Treg marker, seems to be an independent prognostic factor for better OS in the whole NPC group. Therefore, immune-based therapies targeting Tregs should be carefully evaluated. M2 spectrum macrophages are probably more prominent in EBV-negative NPC with also functional differences compared with EBV-positive NPC.