Association of Body Mass Index With Disease Progression in Children With Charcot-Marie-Tooth Disease.
Gabrielle A DonlevyKayla Md CornettSarah P GarnettRosemary ShyTimothy EstilowSabrina W YumKimberly AndersonDavide PareysonIsabella MoroniFrancesco MuntoniMary M ReillyRichard S FinkelDavid N HerrmannKaty J EichingerMichael E ShyJoshua BurnsManoj P MenezesPublished in: Neurology (2023)
Children with CMT who severely underweight, underweight, or obese exhibited greater disability at baseline. Over the 2-year period in those whose BMI remained stable, severely underweight children deteriorated at the fastest rate. For children who changed BMI categories over the 2 years, CMTPedS scores deteriorated faster in children who became overweight/obese. Interventions that maintain or improve BMI towards a healthy weight may reduce disability in children with CMT.