Biodistribution of [(68)Ga]PSMA-HBED-CC in Patients with Prostate Cancer: Characterization of Uptake in Normal Organs and Tumour Lesions.

Vikas PrasadIngo G SteffenGerd DiederichsMarcus R MakowskiPeter WustWinfried Brenner

Published in: Molecular imaging and biology (2017)

This biodistribution study provided a broad range of uptake data of [(68)Ga]PSMA-11 for normal organs/tissues, primary prostate tumours and metastatic lesions based on a large patient cohort. Both PT and small metastatic lesions were detectable due to their high tracer uptake. Four-times-higher median uptake in PT in comparison to normal prostate stroma resulted in a high diagnostic accuracy that could potentially be used for multimodal image-guided biopsy with dedicated reconstruction software.

Keyphrases

pet ct
prostate cancer
pet imaging
positron emission tomography
small cell lung cancer
squamous cell carcinoma
radical prostatectomy
benign prostatic hyperplasia
machine learning
computed tomography
ultrasound guided
data analysis
big data
pain management
artificial intelligence
clinical evaluation