Antigen Experienced T Cells from Peripheral Blood Recognize p53 Neoantigens.
Parisa MalekzadehRami YossefGal CafriBiman C PariaFrank J LoweryMohammad JafferjiMeghan L GoodAbraham SachsAmy R CopelandSanghyun P KimScott KivitzMaria R ParkhurstPaul F RobbinsSatyajit RayLiqiang XiMark RaffeldZhiya YuNicholas P RestifoRobert P T SomervilleSteven A RosenbergDrew C DenigerPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
PBL was a noninvasive source of T cells targeting TP53 mutations for cell therapy and can provide a window into intratumoral p53 neoantigen immune responses.See related commentary by Olivera et al., p. 1203.