Sex-dependent effects of chronic intermittent hypoxia: Implication for obstructive sleep apnea.

Steve MabryJessica L BradshawJennifer J GardnerE Nicole WilsonRebecca L Cunningham

Published in: Research square (2024)

Our results indicate that the impact of CIH is dependent on sex, such as an inflammatory response and OS response in females and males, respectively, that are mediated by mtOS. Interestingly, there was no effect of sex or mtOS in CIH-induced impairment of recollective memory. These results indicate that mtOS is involved in the sex differences observed in CIH, but a different mechanism underlies CIH-induced memory impairments.

Keyphrases

inflammatory response
obstructive sleep apnea
high glucose
diabetic rats
drug induced
working memory
endothelial cells
oxidative stress
lipopolysaccharide induced
positive airway pressure
sleep apnea