DNA Repair Genes as Drug Candidates for Early Breast Cancer Onset in Latin America: A Systematic Review.
Laura Keren Urbina-JaraEmmanuel Martinez-LedesmaAugusto Rojas-MartinezFrancisco Ricardo Rodriguez-RecioRocío Ortíz-LópezPublished in: International journal of molecular sciences (2021)
The prevalence of breast cancer in young women (YWBC) has increased alarmingly. Significant efforts are being made to elucidate the biological mechanisms concerning the development, prognosis, and pathological response in early-onset breast cancer (BC) patients. Dysfunctional DNA repair proteins are implied in BC predisposition, progression, and therapy response, underscoring the need for further analyses on DNA repair genes. Public databases of large patient datasets such as METABRIC, TCGA, COSMIC, and cancer cell lines allow the identification of variants in DNA repair genes and possible precision drug candidates. This study aimed at identifying variants and drug candidates that may benefit Latin American (LA) YWBC. We analyzed pathogenic variants in 90 genes involved in DNA repair in public BC datasets from METABRIC, TCGA, COSMIC, CCLE, and COSMIC Cell Lines Project. Results showed that reported DNA repair germline variants in the LA dataset are underrepresented in large databases, in contrast to other populations. Additionally, only six gene repair variants in women under 50 years old from the study population were reported in BC cell lines. Therefore, there is a need for new approaches to study DNA repair variants reported in young women from LA.
Keyphrases
- dna repair
- dna damage
- copy number
- dna damage response
- early onset
- genome wide
- healthcare
- emergency department
- end stage renal disease
- oxidative stress
- bioinformatics analysis
- mental health
- chronic kidney disease
- early breast cancer
- newly diagnosed
- pregnant women
- genome wide identification
- young adults
- rna seq
- metabolic syndrome
- magnetic resonance imaging
- type diabetes
- late onset
- quality improvement
- mesenchymal stem cells
- bone marrow
- single cell
- replacement therapy
- patient reported
- genome wide analysis