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The chemical biology of IL-12 production via the non-canonical NFkB pathway.

Peter David KochMikaël J PittetRalph Weissleder
Published in: RSC chemical biology (2020)
Interleukin-12 (IL-12) has emerged as an attractive cytokine for cancer therapy because it has direct anti-cancer effects and additionally plays a critical role in enhancing checkpoint inhibitors. Given these multiple modes of actions, identifying means to pharmacologically induce IL-12 production in the tumor microenvironment has become important. In this review, we highlight therapeutics that promote IL-12 induction in tumor-associated myeloid cells through the non-canonical NFkB pathway. We discuss existing clinical trials and briefly examine the additional pathway targets that warrant further exploration for drug discovery.
Keyphrases
  • drug discovery
  • clinical trial
  • cancer therapy
  • induced apoptosis
  • dna damage
  • small molecule
  • bone marrow
  • cell cycle
  • cell cycle arrest
  • cell death