Epigenome-Wide Analysis of Methylation Changes in the Sequence of Gallstone Disease, Dysplasia, and Gallbladder Cancer.

Johannes BrägelmannCarol Barahona PonceKatherine MarcelainStephanie RoesslerBenjamin GoeppertIvan GallegosAlicia ColomboVerónica SanhuezaErik MoralesMaría Teresa RiveraGonzalo de ToroAlejandro OrtegaBettina MüllerFernando GablerDominique SchererMelanie WaldenbergerEva ReischlFelix BoekstegersValentina Garate-CalderonSinan U UmuTrine B RoungeOdilia PopandaJusto Lorenzo Bermejo

Published in: Hepatology (Baltimore, Md.) (2021)

Our results indicate that GBC carcinogenesis comprises three main methylation stages: early (gallstone disease and low-grade dysplasia), intermediate (high-grade dysplasia), and late (GBC). The identified gradual changes in methylation and CNVs may help to enhance our understanding of the mechanisms underlying this aggressive disease and eventually lead to improved treatment and early diagnosis of GBC.

Keyphrases

low grade
high grade
dna methylation
genome wide
gene expression
papillary thyroid
smoking cessation
amino acid
replacement therapy
combination therapy