Single-cell transcriptomics reveals a mechanosensitive injury signaling pathway in early diabetic nephropathy.

Shuya LiuYu ZhaoShun LuTianran ZhangMaja T LindenmeyerViji NairSydney E GiesGuochao WuRobert G NelsonJan CzogallaHande AypekStephanie ZielinskiZhouning LiaoMelanie SchaperDamian FerminClemens D CohenDenis DelicChristian F KrebsFlorian GrahammerThorsten WiechMatthias KretzlerCatherine Meyer-SchwesingerStefan BonnTobias B Huber

Published in: Genome medicine (2023)

Overall, our study presents a comprehensive single-cell transcriptomic landscape of early DN, highlighting mechanosensitive signaling pathways as novel targets of diabetic glomerulopathy.

Keyphrases

single cell
signaling pathway
rna seq
diabetic nephropathy
high throughput
pi k akt
type diabetes
epithelial mesenchymal transition
induced apoptosis
oxidative stress