Identifying high risk clinical phenogroups of pulmonary hypertension through a clustering analysis.

Paula K RambaratEmily K ZernDongyu WangAthar RoshandelpoorShahrooz ZarbafianElizabeth E LiuJessica K WangJenna N McNeillCarl T AndrewsEugene V PomerantsevNathaniel DiamantPuneet BatraSteven A LubitzMichael H PicardJennifer E Ho

Published in: PloS one (2023)

Cluster-based analyses identify patients with PH and specific comorbid cardiometabolic and cardiovascular disease burden that are at highest risk for adverse clinical outcomes. Interestingly, cardiopulmonary hemodynamics were similar across phenogroups, highlighting the importance of multimorbidity on clinical trajectory. Further studies are needed to better understand comorbid heterogeneity among patients with PH.

Keyphrases

cardiovascular disease
pulmonary hypertension
single cell
pulmonary artery
emergency department
pulmonary arterial hypertension
rna seq
metabolic syndrome
coronary artery disease
coronary artery
adverse drug