Pathogenic Potential of Eomesodermin-Expressing T-Helper Cells in Neurodegenerative Diseases.
Tomomi KanazawaWakiro SatoBen J E RaveneyDaiki TakewakiAtsuko KimuraHiromi YamaguchiYuma YokoiReiko SaikaYuji TakahashiTsuneo FujitaShinji SaikiAkira TamaokaShinji OkiTakashi YamamuraPublished in: Annals of neurology (2024)
Eomesodermin-expressing (Eomes + ) T-helper (Th) cells show cytotoxic characteristics in secondary progressive multiple sclerosis. We found that Eomes + Th cell frequency was increased in the peripheral blood of amyotrophic lateral sclerosis and Alzheimer's disease patients. Furthermore, granzyme B production by Th cells from such patients was high compared with controls. A high frequency of Eomes + Th cells was observed in the initial (acutely progressive) stage of amyotrophic lateral sclerosis, and a positive correlation between Eomes + Th cell frequency and cognitive decline was observed in Alzheimer's disease patients. Therefore, Eomes + Th cells may be involved in the pathology of amyotrophic lateral sclerosis and Alzheimer's disease. ANN NEUROL 2024.
Keyphrases
- amyotrophic lateral sclerosis
- cognitive decline
- multiple sclerosis
- end stage renal disease
- induced apoptosis
- high frequency
- ejection fraction
- chronic kidney disease
- newly diagnosed
- prognostic factors
- peritoneal dialysis
- peripheral blood
- stem cells
- single cell
- oxidative stress
- cell proliferation
- patient reported outcomes
- white matter
- climate change