The CD33 short isoform is a gain-of-function variant that enhances Aβ1-42 phagocytosis in microglia.
Abhishek BhattacherjeeJaesoo JungSameera ZiaMadelene HoGhazaleh Eskandari-SedighiChris D St LaurentKelli A McCordArjun BainsGaurav SidhuSusmita SarkarJason R PlemelMatthew Scott MacauleyPublished in: Molecular neurodegeneration (2021)
These results provide strong support that hCD33m represents a gain-of-function isoform and offers insight into what it may take to therapeutically capture the AD-protective CD33 allele.